International name - ibuprofen. Before buy motrin, you must know something about it.
Pharmacological action.
Motrin or motrin generic - non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with inhibition of prostaglandin synthesis.
The drug inhibits the mobility of leukocytes and phagocytosis. Motrin influences the immune processes, breaking the pattern recognition receptors of lymphocytes and thymocytes specific signals.
Anti-inflammatory effect occurs at the end of the first week of treatment. The drug significantly (up to disappearance) reduces the pain, including joint pain at rest and during movement, increases range of motion, reduces morning stiffness and swelling of joints.
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Pharmacokinetics.
After oral administration of Motrin or motrin generic quickly and completely absorbed from the gastrointestinal tract. Bioavailability when taken with food is practically unchanged.
Maximum plasma concentrations are achieved in 1-2 hours.
Binding with plasma protein is 99%.
The drug is metabolized in the liver.
The half-life is 2 hours. Motrin excreted by the kidneys mainly as inactive metabolites, and about 10% - 20% of the drug excreted unchanged.
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Indications for use.
- Rheumatoid arthritis, including juvenile;
- Osteoarthritis;
- Psoriatic arthritis;
- Ankylosing spondylitis;
- An acute bursitis, tendonitis, sciatica;
- Pain of mild to moderate severity (Injury of soft tissues), headache and toothache;
- Excessive menstrual blood loss, including patients who use an intrauterine contraceptive devices.
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Dosage of motrin or motrin generic.
For adults appointed if osteoarthritis, psoriatic arthritis motrin 400 mg or 600 mg 3-4 times a day.
In rheumatoid arthritis, 800 mg 3 times daily, maximum dose - 2.4 g / day.
In juvenile rheumatoid arthritis drug is prescribed in a daily dose of 30-40 mg / kg body weight.
With tendinitis, bursits, radiculitis - 400-600 mg 3-4 times a day.
When soft tissue traumas (sprains) - 1.6-2.4 g / day in divided doses.
In primary dysmenorrhea - 1.2 g / day in divided doses, to reduce excessive menstrual bleeding - 1.6 g / day, from the first signs of bleeding prior to its termination, but not more than 7 days. You should not use the drug for more than 2 cycles.
For a moderate pain syndrome a daily dose prescribed in 1.2 g in divided doses.
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Side effects of motrin or motrin generic.
From the gastrointestinal tract and liver: stomach pain, nausea, vomiting, diarrhea, anorexia.
Urinary system: reported cases of slight hematuria, proteinuria and occasionally nephrotic syndrome.
Allergic reactions: urticaria, angioedema, bronchoconstriction.
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Contraindications.
- Hypersensitivity to ibuprofen and other NSAIDs in history;
- Stomach ulcer and duodenal ulcer.
Controlled clinical researches of Motrin in children has not been conducted.
Is not recommend to use the drug during pregnancy because of possible adverse effects on the fetus.
Overdose of motrin or motrin generic.
Symptoms: The disorder of the gastrointestinal tract, skin rash, headache.
Treatment. In the event of acute overdosage the stomach should be released by washing it.